Lu Research Group
Jun. 2020
In this work, we explored the Thorpe-Ingold effect to construct recyclable polythioesters.
[Graduation] Guangqi Wu and Wei Xiong Thesis Defense
June, 2020.
Guangqi and Wei successfully passed the thesis defense on June 08th, 2020. Guangqi developed chemistry and materials applications for selenopolypetides, whereas Wei focused on stimuli-responsive polypeptides and polyesters.
Congratulations to the two newly minted doctors! Well-done!
Both Guangqi and Wei will continue their PHD research at PKU as postdocs.
[Research] Dr. Zhang Chong’s work highlighted by NANOER.NET
April, 2020.
Dr. Zhang Chong's work on polypeptide orientation-governed cellular uptake, published in Nano Research in 2019, has been selected as one of the 81 most remarkable works published in the 16 domestic journals. Check out the collections and find our work as #21.
Page Link: https://mp.weixin.qq.com/s/j8_KIDmxJtSVXmWPO0pw_Q
PDF Link: https://link.springer.com/article/10.1007/s12274-019-2319-6
[PUBLICATIONS] Several collaborative papers published in 2020.
April, 2020.
Please check them out.
Collaboration work with Prof. Dehai Liang published in Soft Matter
Dongxiao Yin, Hao Wen, Guangqi Wu, Shaolu Li, Chenyang Liu, Hua Lu* and Dehai Liang*, "PEGylated gene carriers in serum under shear flow", Soft Matter, 2020, 16(9), 2301-2310.
https://pubs.rsc.org/en/content/articlelanding/2020/SM/C9SM02397F#!divAbstract
Collaboration work with Prof. Qian Li published in Small
Zhilei Ge, Linjie Guo, Guangqi Wu, Jiang Li, Yunlong Sun, Yingqin Hou, Jiye Shi, Shiping Song, Lihua Wang, Chunhai Fan, Hua Lu* and Qian Li*, "DNA Origami-Enabled Engineering of Ligand–Drug Conjugates for Targeted Drug Delivery", Small, 2020, 16(16), e1904857
https://onlinelibrary.wiley.com/doi/full/10.1002/smll.201904857
Collaboration work with Prof. Bradley Olsen published in Polymer Chemistry
Helen Yao, Kai Sheng, Jialing Sun, Shupeng Yan, Yingqin Hou, Hua Lu and Bradley D. Olsen*, "Secondary structure drives self-assembly in weakly segregated globular protein-rod block copolymers", Polym. Chem., 2020, 11(17), 3032-3045.
https://pubs.rsc.org/en/content/articlelanding/2020/py/c9py01680e#!divAbstract
Collaboration work with Prof. Zhibo Li published in CCS Chemistry
Yong Shen, Wei Xiong, Yongzheng Li, Zhichao Zhao, Hua Lu*, and Zhibo Li*, "Chemoselective Polymerization of Fully Biorenewable α-Methylene-γ-Butyrolactone Using Organophosphazene/Urea Binary Catalysts Toward Sustainable Polyesters", CCS Chem. 2020, 2, 620-630.
https://www.chinesechemsoc.org/doi/10.31635/ccschem.020.202000232
Congratulations to the authors!
[PUBLICATION] Yuan Jingsong published a paper in CCS CHEM.
April, 2020.
In this work, we, in a collaboration with Prof. Er-Qiang Chen, utilized 4-hydroxyproline as the feedstock for making functional aliphatic polyesters. The work opens up new opportunities for sustainable polymers and bioconjugation.
https://www.chinesechemsoc.org/doi/10.31635/ccschem.020.201900119
[PUBLICATIONS] LU Jianhua’s paper published in JACS
Jan. 2020.
The magic of FROZEN: rapid and highly controlled grafting-from synthesis of protein-polydisulfide conjugates. We developed an extremely simple solution to a great challenge in protein-polymer conjugation. The chemistry is so simple that even biologists can do it well. The conjugates made by this method is potentially useful in intracellular protein delivery, traceless release and protein purification. A patent has been filed besed on this technology.
[publications] Xiong Wei’s paper is online in the RSC journal Polymer Chemistry
Oct. 2019.
Xiong Wei developed a novel photo-responsive polypeptides bearing allyloxyazobenzene side-chains that are modifiable via various approaches. The polymer showed interesting liquid crystalline phase behaviors. Please click the following website and check it out. https://doi.org/10.1039/C9PY01106D
This is a nice collaboration with Prof. Shen Zhihao and Prof. Chen Erqiang within our department.
The paper is included as an invited paper for the special issue 2020 Polymer Chemistry Emerging Investigators.
[Group Activity] Trip to the Road of Heaven in Zhangbei Grassland
July 2019.
Summer is here! The group took a 3-day-trip in the grassland nearby Beijing to celebrate the graduation of Dr. Jingsong Yuan and Dr. Yingqin Hou, who will soon start their postdoctoral research in U.S.A. We will miss them and wish them success in the future!
[PUBLICATION] Wang Hao’s first research paper published in Biomacromolecules
July 2019
Congratulations to Hao and our collaborators! In this paper, we report an enzyme cleavable protein-polypeptide conjugate that can simultaneously maintain long circulation and be activated in the tumor environment. Please check it out:
[PUBLICATIONS] Guangqi published his first research paper in Chemical Communications
June, 2019.
Guangqi developed a series of thermal and redox sensitive selenopolypeptides. Rapid and reversible redox controlled helix-coil transitions are realized. These polymers could be useful biomaterials for many applications. Stay tuned for more fun following works, come soon.
https://pubs.rsc.org/en/content/articlelanding/2019/CC/C9CC03767E#!divAbstract
