贾桂芳

教授，博士生导师

研究方向：化员工物学

办公室：C416B
电话：010-627561792
电子信箱：guifangjia@pku.edu.cn
课题组网站：http:/jiagroup/

学术简历

2025.08-至今教授，77779193永利集团化员工物学系
2024.08–2025.07 长聘副教授，77779193永利集团化员工物学系
2020.02–2024.07 助理教授，77779193永利集团化员工物学系
2023-至今研究员，核糖核酸北京研究中心
2021-至今研究员，北大-清华生命科学联合中心
2020-至今研究员，永利集团合成与功能生物分子中心
2012.09-2020.01 副研究员，博士生导师，77779193永利集团，永利集团合成与功能生物分子中心
2009-2012 博士后，美国芝加哥大学
2007-2008 联合培养研究生，美国芝加哥大学
2008 理学博士中国农业大学
2002 理学学士中国农业大学

获奖情况

2024 中国青年女科学家奖
2022 国家杰出青年科学基金
2018 国家优秀青年科学基金

研究领域和兴趣：

与DNA和组蛋白上表观遗传修饰类似，RNA上也存在动态可逆的化学修饰（如首个被发现的可逆RNA修饰N6-甲基腺嘌呤），对RNA加工代谢具有重要的调控功能从而影响基因表达，进而调控一系列重要的生命活动过程和疾病的发生发展。这一新兴表观遗传学研究领域称之为表观转录组学。RNA修饰依赖修饰酶、去修饰酶和结合蛋白三类蛋白调控发挥功能。RNA上存在上百种化学修饰，但大多数生物功能未知。

本课题组致力于开发核酸修饰化学标记测序技术，运用化员工物学、分子生物学、细胞生物学、生物信息学等技术和手段，研究核酸化学修饰和RNA表观遗传学在动植物中的生物调控功能。主要的研究方向包括：

发展核酸修饰化学标记测序技术，实现核酸修饰的全转录组测序和定位，并应用于临床疾病诊断；
鉴定RNA修饰的修饰酶、去修饰酶和结合蛋白及调控网络，阐明RNA修饰对植物生长发育、逆境响应等调控机制；
改造植物RNA修饰，实现植物高产等优质农艺性状；
研究RNA修饰在疾病中的致病分子机制；
发展小分子抑制剂，调控RNA表观遗传修饰。

代表性论文

Peizhe Song^#, Zhihe Cai^#, Subiding Tayier^#, Enlin Tian, Zixin Chen, Kemiao Yu, Guifang Jia*. RNA m⁶A silences the transcription and heterochromatin state of retrotransposons in Arabidopsis. Nature Plants, In Press.
Nini Ma^#, Peizhe Song^#, Yangjie Li, Ziyang Liu, Mengyue Ding, Xuan Ma, Tangdi Luo, Qiutao Xu, Yaping Yue, Dao-Xiu Zhou, Guifang Jia*, Yu Zhao*. Regulation of the N⁶-methyladenosine (m⁶A) RNA reader protein OsECT3 activity by lysine acetylation in cold stress response in rice. Nature Plants, 2025, 11(6), 1165-1180.
Zhihe Cai^#, Qian Tang^#, Peizhe Song^#, Enlin Tian, Junbo Yang, Guifang Jia*. The m⁶A reader ECT8 is an abiotic stress sensor that accelerates mRNA decay in Arabidopsis. Plant Cell, 2024, 36(8), 2908-2926.
Song Cui^#, Peizhe Song^#, Chaolong Wang, Saihua Chen, Benyuan Hao, Zhuang Xu, Liang Cai, Xu Chen, Shanshan Zhu, Xiangchao Gan, Hui Dong, Yuan Hu, Liang Zhou, Haigang Hou, Yunlu Tian, Xi Liu, Liangming Chen, Shijia Liu, Ling Jiang, Haiyang Wang, Guifang Jia*, Shirong Zhou^*, Jianmin Wan^*. The RNA binding protein EHD6 recuits the m6A reader YTH07 and sequesters OsCOL4 mRNA into phase-separated ribonucleoprotein condensates to promote rice flowering. Molecular Plant, 2024, 17 (6), 935-954.
Mengyan Bai^#, Wenxin Lin^#, Chunyan Peng^#, Peizhe Song^#, Huaqin Kuang, Jieni Lin, Jieping Zhang, Jiyao Wang, Bo Chen, Huarong Li, Fanjiang Kong, Guifang Jia*, Yuefeng Guan*. Expressing a human RNA demethylase as an assister improves gene-editing efficiency in plants. Molecular Plant, 2024, 17, 363-366.
Hong-Chao Duan^#, Chi Zhang^#, Peizhe Song, Junbo Yang, Ye Wang, Guifang Jia*. C²-methyladenosine in tRNA promotes protein translation by facilitating the decoding of tandem m²A-tRNA-dependent codons. Nature Communications, 2024, 15(1):1025.
Lin Zhang^#, Hong-Chao Duan^#, Marcin Paduch^#, Jingyan Hu, Chi Zhang, Yajuan Mu, Houwen Lin, Chuan He, Anthony A. Kossiakoff, Guifang Jia*, Liang Zhang*. The molecular basis of human ALKBH3 mediated RNA N¹-methyladenosine (m¹A) demethylation. Angewandte Chemie International Edition, 2024, 63(7), e202313900.
Qiong Yu^#, Shun Liu^#, Lu Yu, Yu Xiao, Shasha Zhang, Xueping Wang, Yingying Xu, Hong Yu, Yulong Li, Junbo Yang, Jun Tang, Hong-Chao Duan, Lian-Huan Wei, Haiyan Zhang, Jiangbo Wei, Qian Tang, Chunling Wang, Wutong Zhang, Ye Wang, Peizhe Song, Qiang Lu, Wei Zhang, Shunqing Dong, Baoan Song*, Chuan He*, Guifang Jia*. RNA demethylation increases the yield and biomass of rice and potato plants in the field trials. Nature Biotechnology, 2021, 39, 1581-1588.
Ye Wang, Yu Xiao, Shunqing Dong, Qiong Yu, Guifang Jia*. Antibody-free enzyme-assisted chemical approach for detection of N⁶-methyladenosine. Nature Chemical Biology, 2020, 16, 896-903.
Xiao Zhang^#, Lian-Huan Wei^#, Yuxin Wang^#, Yu Xiao^#, Jun Liu, Wei Zhang, Ning Yan, Gubu Amu, Xinjing Tang, Liang Zhang*, Guifang Jia*. Structural insights into FTO's catalytic mechanism for the demethylation of multiple RNA substrates. Proceedings of National Academy of Sciences of the United States of America, 2019, 116, 2919.